Animal study · 2018
Stable Gastric Pentadecapeptide BPC 157 and Tendon Healing Mechanisms
Chang CH, Tsai WC, Hsu YH, et al. · Journal of Applied Physiology / preclinical series
Rat Achilles-tendon models show accelerated fibroblast outgrowth and improved biomechanical strength with BPC-157, mediated through VEGFR2 and FAK-paxillin signaling.
Key findings
- Increased tendon fibroblast survival and migration in vitro
- Higher load-to-failure in treated tendons
- Effects blocked by VEGFR2 inhibition
Limitations
No randomized human data exists. Rodent dosing does not translate reliably, and human safety is uncharacterized.